Predictive Pharmacodynamic Performance of the Eleveld Pharmacokinetic-Pharmacodynamic Model for Propofol: Comparison of Predicted and Measured Bispectral Index

Medicine, Anesthesiology,
Propofol   Pharmacokinetics   Pharmacodynamics   Bispectral Index   Intravenous Anaesthesia   Computer Simulation   Prediction Error  

In the field of anesthesiology, propofol is a widely used intravenous anesthetic, and its pharmacokinetic (PK) and pharmacodynamic (PD) models are crucial for precise control of anesthetic depth. The Eleveld model is a widely applied PK-PD model for propofol, capable of predicting propofol plasma concentrations, effect-site concentrations, and the ...