The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Combined Single-Cell and Spatial Transcriptome Analysis Reveals Cellular Heterogeneity of the Hedgehog Pathway in Gastric Cancer Academic Background Gastric cancer (GC) is one of the most common and deadly malignancies worldwide, with high incidence and mortality rates. Despite advancements in chemotherapy, radiotherapy, and targeted therapy, the t...

Potential Coagulation-Related Diagnostic Model Associated with Immune Infiltration for Acute Myocardial Infarction Academic Background Acute Myocardial Infarction (AMI) is one of the leading causes of death worldwide. Despite significant advancements in diagnosis, treatment, and prognosis in recent years, the incidence and mortality rates of AMI re...

Academic Background Liver regeneration is a complex biological process involving the coordinated action of various cell types and signaling pathways. Following partial liver resection, the remaining liver tissue restores its function and mass through a series of precisely regulated cell proliferation and immune responses. Although extensive researc...

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data Authors: Jianlan Hu1, Youxing Wu1, Danxia Zhang1, Xiaoyang Wang1, Yaohui Sheng1, Hui Liao1, Yangpeng Ou2✉, Zhen Chen3, Baolian Shu1✉, and Ruohu Gui1✉ Journal: Genes & Immunity (2024) 25:492–513 DOI: https://doi.org/10.1038...

Effectiveness of Neoantigen-Specific mRNA/DC Vaccines in Anticancer Immunotherapy Academic Background Cancer immunotherapy has emerged as a significant breakthrough in cancer treatment in recent years. Among the various approaches, dendritic cell (DC) vaccines have shown potential in extending the survival of some advanced cancer patients. However,...

Revolutionary Self-Powered Glucose Monitoring Mechanism: Microengineered Paper-Based Platform with Microbial Spores Academic Background Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications such as cardiovascular diseases, retinopathy, kidney failure, and neuropathy. The glob...

Automated Analysis of Ultrastructure: A Study Based on Large-Scale Hyperspectral Electron Microscopy Academic Background Electron Microscopy (EM) is a key technique for studying biological ultrastructure, revealing the fine details of cells at biomolecular resolution. In recent years, advancements in automation and digitization have enabled EM to c...

Fiber Optics-Based Surface Enhanced Raman Spectroscopy Sensors for Rapid Multiplex Detection of Foodborne Pathogens in Raw Poultry Academic Background Foodborne illnesses are a significant global public health challenge, with Salmonella being one of the leading pathogens causing such diseases. In the United States alone, Salmonella results in 1.35 ...

Fabrication and In Vivo Testing of a Sub-mm Duckbill Valve for Hydrocephalus Treatment Academic Background Hydrocephalus is a complex pathological condition characterized by the accumulation of cerebrospinal fluid (CSF) in the cranium due to an imbalance between CSF production and absorption. This accumulation leads to increased intracranial pressu...