Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...
Study of Somite Formation Model Based on Microfluidic System Background and Research Motivation The formation of somites plays a crucial role in vertebrate embryonic development, significantly influencing the layout and functionality of the embryonic musculoskeletal system. Somite formation involves the segmentation of bilateral presomitic mesoderm...
Lipid Metabolism Mechanisms in Neurodegenerative Diseases: A New Study on Multiple Sclerosis Multiple Sclerosis (MS) is a common inflammatory autoimmune demyelinating disease of the central nervous system (CNS). As the disease progresses, patients gradually experience neurological damage and disability. Although there have been advances in the trea...
Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...
Metabolic and Epigenetic States of HSC-Derived Macrophages in Autoimmune Diseases and Their Driving Mechanism of Trained Immunity Research Background In the context of autoimmune diseases (AD), studies have shown that prolonged activation of the immune system and inflammatory responses affect not only mature immune cells but also have profound effe...
Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...
Modeling the Atrioventricular Conduction Axis Based on Human Pluripotent Stem Cell-Derived Cardiac Assembloids Research Background The atrioventricular (AV) conduction axis is responsible for electrical conduction between the atrium and the ventricle and is a core component of the cardiac electrophysiological system. The delay function of AV conduc...
Alveolar Regeneration: Role of p63+ Progenitor Cells Derived from Airway Secretory Cells Background Introduction Effective gas exchange in the lungs relies on the precise structure and function of various epithelial cells, distributed across two distinct structural regions: ductal airways and alveoli. When alveoli are damaged (e.g., due to inhaled ...
Background Introduction This study explores the landscape of individual drug sensitivity and resistance in sarcoma patients. Sarcomas are a diverse group of tumors originating from mesenchymal tissue, including types such as osteosarcoma and soft tissue sarcoma, mostly affecting young people. Although the annual incidence of sarcomas is relatively ...
Differences in Signaling Requirements for Trophoblast Stem Cells between Humans and Marmosets Background and Research Motivation Embryo implantation and placenta formation are critical features of eutherian mammalian development. The trophoblast is a group of outer cells of the embryo that mediates the connection between the embryo and maternal tis...