The Impact of Inflammation on Brain Delivery of Oxycodone Academic Background Oxycodone is a widely used opioid analgesic with a unique property of being actively transported from the blood to the brain across the blood-brain barrier (BBB). This process is believed to be associated with the proton-coupled organic cation (H+/OC) antiporter system. H...

The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...

Repeated Exposure to Sevoflurane Impairs GABAergic Neuronal Development and Social Cognitive Function in the Hippocampal CA2 Region of Mice Academic Background Approximately 1.5 million infants and young children undergo medical procedures requiring general anesthesia annually, with sevoflurane being widely used in pediatric anesthesia. However, in...

Personalized Perioperative Dosing of Ivabradine in Noncardiac Surgery: A Single-Centre, Randomised, Placebo-Controlled, Double-Blind Feasibility Pilot Trial Academic Background Perioperative myocardial injury (PMI) is a common complication following noncardiac surgery and is closely associated with postoperative mortality and morbidity. Studies hav...

Lifetime Risk of Surgery in England: A Nationwide Observational Cohort Study Academic Background Surgery represents a significant portion of the UK National Health Service (NHS) activity, with approximately 4.4 million people undergoing surgical procedures in England each year. Although an increasing number of surgeries are performed as day-case pr...

In the field of anesthesiology, propofol is a widely used intravenous anesthetic, and its pharmacokinetic (PK) and pharmacodynamic (PD) models are crucial for precise control of anesthetic depth. The Eleveld model is a widely applied PK-PD model for propofol, capable of predicting propofol plasma concentrations, effect-site concentrations, and the ...

Effects of Inhalation versus Total Intravenous Anaesthesia on Long-Term Mortality in Older Patients after Noncardiac Surgery: A Retrospective Observational Study Academic Background With the global aging phenomenon, the number of elderly patients undergoing surgery is increasing year by year. Elderly patients are more susceptible to adverse effects...

Distribution and Outcomes of Paediatric Anaesthesia Services in Sweden: An Epidemiological Study Academic Background In recent years, there has been a growing trend towards the centralization of perioperative care for children globally, particularly in European countries. This trend is primarily driven by research findings from professional organiz...

Dopaminergic Psychostimulants Restore Arousal from Isoflurane-Induced Sedation Without Reversing Memory Impairment in Rats Academic Background The widespread use of anesthetic drugs in surgery allows patients to undergo treatment without pain. However, the impact of anesthetic drugs on memory has been a significant research topic in the field of an...

The Effect of a Comfort Scale Compared with a Pain Numerical Rating Scale on Opioid Consumption in the Post-Anaesthesia Care Unit: The COMFORT Study Academic Background Postoperative pain management is a critical topic in anaesthesiology and intensive care medicine. Effective pain assessment tools can help physicians optimize postoperative analgesi...