Overcoming the Preferred-Orientation Problem in Cryo-EM with Self-Supervised Deep Learning

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Biochemistry, Biophysics,
cryo-EM   preferred-orientation problem   self-supervised learning   deep learning   3D reconstruction   molecular structure   biological macromolecules  

Overcoming the Preferred-Orientation Problem in Single-Particle Cryo-EM: An Innovative Solution through Deep Learning Background Introduction In recent years, single-particle cryogenic electron microscopy (Single-Particle Cryo-EM) has become a core technique in structural biology due to its ability to resolve the atomic-resolution structures of bio...