Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Computational Modeling of Receptive Field Construction in Midget Ganglion Cells of Primate Retina

Computational Modeling Study on the Construction of Receptive Fields in Midget Ganglion Cells of Primate Retina Academic Background The midget pathway in the primate retina is the foundation for high spatial resolution and color perception in the visual system. A key feature of this pathway is the center-surround organization of the receptive field...

The Geometry of Correlated Variability Leads to Highly Suboptimal Discriminative Sensory Coding

Correlated Variability in the Brain Leads to Highly Suboptimal Sensory Coding Academic Background The brain perceives the world through the activity of neural populations, but it remains unclear whether the computational goal of sensory coding is to support the discrimination of sensory stimuli or to generate an internal model of the sensory world....

Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

The Regulatory Role of Dopamine Receptors in the Thalamic Reticular Nucleus: A Study on Neuronal Excitability and Electrical Synapses Academic Background The Thalamic Reticular Nucleus (TRN) is a crucial inhibitory neuronal network in the brain, responsible for regulating the transmission of sensory information between the thalamus and the cortex. ...

Chilean Brush-Tailed Mouse (Octodon degus): A Diurnal Precocial Rodent as a New Model to Study Visual Receptive Field Properties of Superior Colliculus Neurons

The Chilean Brush-tailed Mouse (Octodon degus) as a New Model for Studying the Visual System Academic Background The study of the visual system has always been an important topic in the field of neuroscience. Traditionally, scientists have used nocturnal or crepuscular rodents (such as hamsters, rats, and mice) as models to study the development an...

Estimating Descending Activation Patterns from EMG in Fast and Slow Movements Using a Model of the Stretch Reflex

Estimating Descending Activation Patterns from EMG in Fast and Slow Movements Using a Stretch Reflex Model Background In the field of motor control, descending activation from the brain is the primary source of muscle activation, but spinal reflex loops also play a significant role in movement generation. The spinal stretch reflex is a short-latenc...

Improving Localization and Measurements of M-Waves Using High-Density Surface Electromyography

Improving Localization and Measurement of M-Waves Using High-Density Surface Electromyography Academic Background Surface electromyography (sEMG) is an important tool for studying muscle function and controlling prosthetics. However, its effectiveness is often limited by cross talk from nearby muscles, especially in densely packed areas like the fo...

Recovery from Spreading Depolarization is Slowed by Aging and Accelerated by Antioxidant Treatment in Locusts

The Impact of Aging and Antioxidants on the Recovery from Spreading Depolarization in Locusts Academic Background Spreading Depolarization (SD) is a phenomenon that temporarily shuts down neural processing in both mammals and insects. In humans, SD is associated with various pathological states, such as migraine aura and neuronal death following tr...

Perisaccadic Perceptual Mislocalization Strength Depends on the Visual Appearance of Saccade Targets

New Findings in Visual Perception and Eye Movement Research Background Introduction In daily life, despite the constant rapid eye movements (known as saccades), we are still able to perceive a stable visual environment. This stability is achieved through the integration of information by the visual system during saccades. However, the mechanisms of...

Differential Contributions of the C1 ERP and Broadband High-Frequency Activity to Visual Processing

Differential Contributions of High-Frequency Activity and C1 ERP Component to Visual Processing: A Combined EEG-MEG Study Academic Background In the field of neuroscience, understanding how visual information is processed in the brain is a central question. Visual information processing is typically divided into two main processes: feedforward and ...