Mevalonate Kinase Inhibits Anti-Tumor Immunity by Impairing the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer

Medicine, Oncology, Life Sciences, Immunology,
Mevalonate Kinase   Microsatellite Instability Colorectal Cancer   Interferon Response   Immune Checkpoint Blockade   Cholesterol Metabolism  

Mevalonate Kinase Impairs Anti-Tumor Immunity by Inhibiting the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer Academic Background Immune checkpoint blockade (ICB) therapy, particularly anti-PD-1 monoclonal antibodies, has been approved for the treatment of microsatellite instability colorectal cancer (MSI ...