GCLink: A Graph Contrastive Link Prediction Framework for Gene Regulatory Network Inference

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Bioengineering, Genetics,
Gene Regulatory Networks   Single-cell RNA Sequencing   Graph Contrastive Learning   Link Prediction   Machine Learning  

Research Background Gene Regulatory Networks (GRNs) are crucial tools for understanding the complex biological processes within cells. They reveal the interactions between Transcription Factors (TFs) and target genes, thereby controlling gene transcription and regulating cellular behavior. With the advancement of single-cell RNA sequencing (scRNA-s...