The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Combined Single-Cell and Spatial Transcriptome Analysis Reveals Cellular Heterogeneity of the Hedgehog Pathway in Gastric Cancer Academic Background Gastric cancer (GC) is one of the most common and deadly malignancies worldwide, with high incidence and mortality rates. Despite advancements in chemotherapy, radiotherapy, and targeted therapy, the t...

Potential Coagulation-Related Diagnostic Model Associated with Immune Infiltration for Acute Myocardial Infarction Academic Background Acute Myocardial Infarction (AMI) is one of the leading causes of death worldwide. Despite significant advancements in diagnosis, treatment, and prognosis in recent years, the incidence and mortality rates of AMI re...

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data Authors: Jianlan Hu1, Youxing Wu1, Danxia Zhang1, Xiaoyang Wang1, Yaohui Sheng1, Hui Liao1, Yangpeng Ou2✉, Zhen Chen3, Baolian Shu1✉, and Ruohu Gui1✉ Journal: Genes & Immunity (2024) 25:492–513 DOI: https://doi.org/10.1038...

Nucleosome Fibre Topology Guides Transcription Factor Binding to Enhancers Academic Background The establishment of cellular identity relies on the concerted action of multiple transcription factors (TFs) bound to enhancers of cell-type-specific genes. Although TFs recognize specific DNA motifs within accessible chromatin, this information alone is...

Academic Background and Problem Statement In cancer research, gene amplification is a common form of mutation, particularly in the activation of oncogenes. However, despite the widely recognized importance of gene amplification in cancer, precisely modeling these amplifications in primary cells and model organisms remains a challenge. Specifically,...

Academic Background Duchenne Muscular Dystrophy (DMD) is a severe X-linked recessive disorder characterized by progressive muscle wasting, leading to premature mortality. The cause of DMD is mutations in the gene encoding dystrophin, a protein that, along with other proteins at the muscle cell membrane, forms the Dystrophin-Glycoprotein Complex (DG...

Report on the Academic Paper Paper Source The paper, titled “Modulation of TCR Stimulation and Pifithrin-α Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells,” was authored by Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, and others from institutions such as the Technical University of Munich and the University of Freiburg Me...

Research Background The asymmetric distribution of proteins in single-cell embryos is a critical step in cell polarity and development. This asymmetry often relies on complex reaction-diffusion mechanisms and involves multiple feedback loops. In the one-cell embryo of Caenorhabditis elegans (C. elegans), the RNA-binding proteins MEX-5 and MEX-6, al...

Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase Academic Background In humans and other mammals, although the genome of each somatic cell is essentially the same, the functions of different cell types vary significantly. This diversity is primarily determined by the binding of transcription factors (...