Structural Insights into Spliceosome Fidelity: DHX35–GPATCH1-Mediated Rejection of Aberrant Splicing Substrates
Academic Background Introduction The spliceosome is a highly dynamic macromolecular complex responsible for the precise excision of introns from pre-mRNA. Although recent advances in cryo-electron microscopy (cryo-EM) have provided a comprehensive structural understanding of the stepwise assembly, catalytic splicing, and final disassembly of the sp...