Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha‑Synuclein via Nrf2‑Mediated Ubiquitin–Proteasome System Activation

Medicine, Neurology,
Parkinson's Disease   Tetramethylpyrazine Nitrone   Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha   Nuclear Factor Erythroid 2-Related Factor 2   Ubiquitin-Proteasome System   Alpha-Synuclein  

Tetramethylpyrazine Nitrone Promotes α-Synuclein Clearance: NRF2-Mediated UPS Activation Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by the degeneration of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, with α-synuclein (α-syn) aggregation as the main component. ...