Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, characterized by motor dysfunction, loss of dopaminergic neurons, and abnormal accumulation of alpha-synuclein (α-syn). Although the cause of most PD cases remains unclear, approximately 5%-10% of cases are due to monogenic mutations. The SNCA gene, w...

Parkinson’s Disease Mouse Model: IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration As research into the pathogenesis of Parkinson’s Disease (PD) deepens, the role of neuroinflammation in PD is gradually being revealed. This study by Simone Bido and his team, published in “Science Translational Medicine”, explores the effects of t...

Tetramethylpyrazine Nitrone Promotes α-Synuclein Clearance: NRF2-Mediated UPS Activation Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by the degeneration of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, with α-synuclein (α-syn) aggregation as the main component. ...

Topographical Map of the 1/f Index in the Whole Brain for Parkinson’s Disease Authors: Pascal Helson, Daniel Lundqvist, Per Svenningsson, Mikkel C. Vinding, Arvind Kumar Research Background Parkinson’s Disease (PD) is a progressive and debilitating brain disorder primarily characterized by motor dysfunction but also affecting perceptual and cogniti...

Parkinson’s Disease Research Report: Subthalamic Nucleus–Language Network Functional Connectivity Predicts Dopaminergic Modulation of Speech Function Background Parkinson’s disease (PD) is primarily characterized by motor impairments, but it also involves non-motor symptoms including speech disorders, severely affecting patients’ quality of life. A...