Construction of human 3D striato-nigral assembloids to recapitulate medium spiny neuronal projection defects in Huntington’s disease
Constructing Human 3D Striatum-Substantia Nigra Organoids to Model Medium Spiny Neuron Projection Deficits in Huntington’s Disease Background Introduction Huntington’s Disease (HD) is a neurodegenerative disorder leading to significant deterioration of the motor system, primarily characterized by defects in medium spiny neurons (MSNs) that project ...