The Impact of Nanotopography on Cellular Metabolic Activities: Multimodal Imaging Reveals New Insights Academic Background In the field of biomedicine, the interaction between cells and material surfaces is crucial for studying cell behavior, tissue engineering, and regenerative medicine. Nanoscale surface topography (nanotopography) has been shown...

Applications of Volumetric Additive Manufacturing in Cell Printing Academic Background Volumetric Additive Manufacturing (VAM) is a revolutionary 3D printing technology capable of rapidly creating complex three-dimensional structures, particularly in the field of cell printing. VAM can mimic the structures of natural tissues, offering new possibili...

Self-Assembled DNA-Collagen Bioactive Scaffolds Promote Cellular Uptake and Neuronal Differentiation Academic Background In molecular biology research, the interaction between DNA and proteins has always been a crucial topic for understanding cellular processes. With the deepening understanding of DNA-protein interactions, this knowledge has been w...

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Mechanism of Stromal Fibroblasts in Breast Cancer Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and metastasis is the leading cause of death in breast cancer patients. The lung is one of the most common sites of breast cancer metastasis, yet the mechanisms underlying this process rema...

The New Role of BOK Protein in Calcium Signaling Regulation Background Introduction BOK (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family and has long been thought to play a role in cell apoptosis. However, recent studies suggest that BOK may also have non-apoptotic functions, particularly in the regulation of calcium ion (Ca²⁺...

SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction Research Background Osteoporosis is a common bone disease characterized by reduced bone density and disrupted bone microstructure, leading to an increased risk of fractures. Osteoclasts, the primary cells responsible for bone resorption, play a cri...

Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...

Targeting ERK1/2 and p38 MAPK Pathways Attenuates Golgin-97 Depletion-Induced Breast Cancer Progression Research Background Breast cancer is the most common type of cancer among women worldwide, with triple-negative breast cancer (TNBC) having a particularly high metastasis rate and poor prognosis. TNBC lacks expression of estrogen receptor, proges...

The Role of Histone Demethylases in Autophagy and Inflammation Background Introduction Autophagy is an essential lysosomal degradation process in eukaryotic cells, playing a critical role in cellular component renewal and homeostasis maintenance. Dysregulation of autophagy is associated with various diseases, including cancer, inflammatory diseases...