Glutamate Dehydrogenase 1-Catalytic Glutaminolysis Feedback Activates EGFR/PI3K/AKT Pathway and Reprograms Glioblastoma Metabolism
Academic Background Glioblastoma (GBM) is one of the most aggressive and heterogeneous central nervous system tumors, with an extremely poor prognosis. Despite the emergence of novel therapies such as anti-angiogenic treatments and immunotherapy in recent years, the survival period of GBM patients remains very limited. GBM cells exhibit unique meta...