Development of Multiplexed Orthogonal Base Editor (MOBE) Systems

Life Sciences, Bioengineering, Genetics,
multiplex editing   orthogonal base editors   genome editing   point mutations   high-fidelity Cas9  

In recent years, with the rapid development of gene editing tools, especially the introduction of the CRISPR-Cas9 system, it has become possible to precisely modify specific DNA sequences. Currently, the introduction of single-nucleotide variants (SNVs) as a powerful tool for studying gene function and disease associations is particularly important...