Internal Feedback Circuits Among MEX-5, MEX-6, and PLK-1 Maintain Faithful Patterning in the Caenorhabditis elegans Embryo

Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
reaction-diffusion   RNA binding proteins   MEX-5   MEX-6   PLK-1   polarity feedback loops   Monte Carlo simulations  

Research Background The asymmetric distribution of proteins in single-cell embryos is a critical step in cell polarity and development. This asymmetry often relies on complex reaction-diffusion mechanisms and involves multiple feedback loops. In the one-cell embryo of Caenorhabditis elegans (C. elegans), the RNA-binding proteins MEX-5 and MEX-6, al...