G Protein–Coupled Receptor Endocytosis Generates Spatiotemporal Bias in β-Arrestin Signaling

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry,
G protein–coupled receptor   β-arrestin   endocytosis   signal bias   functional selectivity   agonist efficacy   receptor signaling  

Academic News Report: The Temporal and Spatial Bias in β-arrestin Signal Transduction Mediated by G Protein-Coupled Receptor Endocytosis Research Background Among cell surface receptor families, G protein-coupled receptors (GPCRs) constitute the largest family. Upon activation by ligands, they interact with various signaling proteins to trigger int...