A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...

The Role of KV7 Channels in Modulating Tension and Calcium Signaling in Mouse Corpus Cavernosum

Study on the Role of KV7 Channels in Regulating Smooth Muscle Contraction in Mouse Corpus Cavernosum Academic Background Erectile dysfunction (ED) is a significant health issue that impacts the quality of life for men. Since the introduction of phosphodiesterase 5 (PDE5) inhibitors like Sildenafil in the 1990s, there has been notable progress in th...

Intestinal Epithelium–Derived IL-34 Reprograms Macrophages to Mitigate Gastrointestinal Tract Graft-Versus-Host Disease

Academic Report on the Role of Intestinal Epithelium-Derived IL-34 in Alleviating Graft-versus-Host Disease 1. Academic Background Graft-versus-Host Disease (GVHD) is a severe complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), and gastrointestinal (GI) GVHD is the primary determinant of morbidity and mortality du...

5-HT Orchestrates Histone Serotonylation and Citrullination to Drive Neutrophil Extracellular Traps and Liver Metastasis

5-HT Orchestrates Histone Serotonylation and Citrullination to Drive Neutrophil Extracellular Traps and Liver Metastasis

Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...

5-HT7R Enhances Neuroimmune Resilience and Alleviates Meningitis by Promoting CCR5 Ubiquitination

5-HT7R Enhances Neuroimmune Resilience and Alleviates Meningitis by Promoting CCR5 Ubiquitination Academic Background Bacterial meningitis is a rapidly onset, highly fatal disease with epidemic potential, especially when caused by Streptococcus pneumoniae (S.p.) infection. The destruction of the blood-brain barrier (BBB) leads to the release of inf...

Kidney Fibrosis in In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Mechanisms and Research Models of Kidney Fibrosis: Progress Toward Physiologically Relevant Humanized Models Research Background and Problem Statement Chronic Kidney Disease (CKD) is a major global public health issue, estimated to affect more than 10% of the population and is one of the leading causes of mortality. Kidney fibrosis, as a key pathol...

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

A Dual-Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide-Induced Sepsis

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...

Enhanced Antigen Capture via Cholinephosphate-Mediated Cell Membrane Interactions to Improve In Situ Tumor Vaccines

Enhanced Antigen Capture via Cholinephosphate-Mediated Cell Membrane Interactions to Improve In Situ Tumor Vaccines

Choline Phosphate-Based Antigen Capture Strategy Boosts In Situ Tumor Vaccine Research: A Novel Immunotherapy Approach In the field of cancer immunotherapy, in situ tumor vaccines have garnered significant attention for their ability to harness a patient’s immune system to target tumors. However, challenges remain in their clinical application. To ...

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Academic Report on “Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss” Background Muscle tissues constitute a significant portion of human cellular mass and are a complex, highly vascularized, and dynamic tissue. However, traumatic or surgical Volumetric Muscle Loss (VML)—defined as the loss o...