G Protein–Coupled Receptor Endocytosis Generates Spatiotemporal Bias in β-Arrestin Signaling

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry,
G protein–coupled receptor   β-arrestin   endocytosis   signal bias   functional selectivity   agonist efficacy   receptor signaling  

Academic News Report: The Temporal and Spatial Bias in β-arrestin Signal Transduction Mediated by G Protein-Coupled Receptor Endocytosis Research Background Among cell surface receptor families, G protein-coupled receptors (GPCRs) constitute the largest family. Upon activation by ligands, they interact with various signaling proteins to trigger int...

ABHD6 Drives Endocytosis of AMPA Receptors to Regulate Synaptic Plasticity and Learning Flexibility

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
AMPA receptors   ABHD6   endocytosis   synaptic plasticity   learning flexibility  

ABHD6 Drives Endocytosis of AMPA Receptors to Regulate Synaptic Plasticity and Learning Flexibility Research Background In the exploration of the neural system’s mechanisms, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) maintain the tuning ability of neurons in both resting and active states through the regulation of...