CD28 Costimulation Augments CAR Signaling in NK Cells via the Lck/CD3ζ/ZAP70 Signaling Axis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CD28   CAR-NK cells   Cancer Therapy   Signaling   Lck   ZAP70   Cytotoxicity  

The Costimulatory Role of CD28 Enhances the Function of CAR-NK Cells through the LCK/CD3ζ/ZAP70 Signaling Axis Research Background and Objective Chimeric Antigen Receptor (CAR) T-cell therapy has shown significant effects in treating certain advanced cancer patients. However, CAR-T cell therapy has many limitations, such as high cost, complex prepa...