Coactivation of Innate Immune Suppressive Cells Induces Acquired Resistance Against Combined TLR Agonism and PD-1 Blockade

Medicine, Oncology, Life Sciences, Immunology,
innate immune suppressive cells   acquired resistance   TLR agonists   PD-1 blockade   tumor microenvironment   CXCL1-CXCR2 axis   polymorphonuclear myeloid-derived suppressor cells  

Mechanism of Combined Immune Checkpoint Blockade Therapy Academic Background Immune Checkpoint Blockade (ICB) is a revolutionary cancer treatment aimed at reactivating effector T cells to combat cancer. However, more than half of patients do not respond to ICB, especially those with immunologically “cold” tumors (tumors with fewer immune cells in t...