Study on Connexin43-Mediated Temozolomide Resistance in Glioma through Activation of the E2F1/ERCC1 Axis Academic Background Glioma is the most common and fatal tumor of the central nervous system, with temozolomide (TMZ) being the standard treatment. However, TMZ therapy often leads to tumor recurrence and drug resistance, severely limiting its ef...
PD-L1 in Tumor-Derived Extracellular Vesicles Promotes T Cell Senescence through Lipid Metabolism Reprogramming Academic Background In recent years, immunotherapy has shown great promise in cancer treatment, particularly in checkpoint blockade therapies targeting PD-1/PD-L1 (programmed cell death protein 1 and its ligand) and CTLA-4 (cytotoxic T-ly...
Mechanism of Combined Immune Checkpoint Blockade Therapy Academic Background Immune Checkpoint Blockade (ICB) is a revolutionary cancer treatment aimed at reactivating effector T cells to combat cancer. However, more than half of patients do not respond to ICB, especially those with immunologically “cold” tumors (tumors with fewer immune cells in t...
Using Liposomal Doxorubicin Neoadjuvant Chemotherapy to Enhance Immune Protection of Tumor Membrane Antigen-Based Nanovaccine Background and Significance Surgical resection remains the primary treatment for solid tumors, but postoperative tumor recurrence and metastasis continue to be major challenges. A promising emerging strategy in personalized ...
Research Report on Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely low survival rate, with a 5-year survival rate of less than 15%. The primary reasons are early tumor metastasis and high resistance to chemotherapy and ra...
Background Introduction This study focuses on malignant pleural mesothelioma (MPM), a rare and highly lethal cancer strongly associated with asbestos exposure. Most patients are diagnosed at advanced stages, with a survival time of only 12 to 15 months, and traditional treatments revolve around platinum-based chemotherapy. However, treatment paradi...
Research on a New Platform for Tumor-Specific Drug Delivery Targeting the Warburg Effect Cancer remains a global health challenge. Traditional cancer treatments, such as chemotherapy and radiotherapy, often come with significant side effects due to their inability to distinguish between tumor tissues and healthy tissues, leading to damage in the la...
3D Bioprinting of Tumor Models and Their Potential Applications: A Review Academic Background Cancer is one of the leading causes of human mortality worldwide. Its uncontrolled abnormal proliferation, rapid growth, metastasis, and high heterogeneity result in extremely low clinical translation rates for traditional two-dimensional (2D) cell culture...
Transcriptomic Concordance Between Borderline Ovarian Tumors and Endometrioid Carcinoma: A Research Study Background Introduction Borderline ovarian tumors (BOTs) are ovarian neoplasms that lie between benign and malignant tumors, typically occurring in young women. Although BOTs are clinically non-invasive, they can occasionally progress to malign...
Exploring Cervical Adenocarcinoma: Epidemiology, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms Academic Background Cervical cancer poses a significant threat to women’s health globally, particularly in developing countries. The main histological types of cervical cancer include squamous cell carcinoma (SCC) and cervical adenoca...