The Proprotein Convertase Furin as a Novel Aneurysm Predisposition Gene Impairing TGF-β Signalling

Academic Background Aortic aneurysm (AA) is a condition characterized by abnormal dilation of the aorta, commonly occurring in the abdominal and thoracic aorta. Aortic aneurysms are more prevalent in individuals over the age of 65, and if not diagnosed and treated promptly, they can lead to fatal ruptures. Although age, smoking, hypertension, and m...