The Proprotein Convertase Furin as a Novel Aneurysm Predisposition Gene Impairing TGF-β Signalling

Medicine, Cardiovascular System, Life Sciences, Genetics,
aortic aneurysm   Furin   TGF-β signalling   proprotein convertase   genetic predisposition  

Academic Background Aortic aneurysm (AA) is a condition characterized by abnormal dilation of the aorta, commonly occurring in the abdominal and thoracic aorta. Aortic aneurysms are more prevalent in individuals over the age of 65, and if not diagnosed and treated promptly, they can lead to fatal ruptures. Although age, smoking, hypertension, and m...

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice

Medicine, Cardiovascular System,
aortic aneurysm   endothelial cells   heterogeneity   site-specificity   RNA-seq  

Site-Specific Genetic and Functional Signatures of Aortic Endothelial Cells at Aneurysm Predilection Sites in Healthy and AngII ApoE−/− Mice Academic Background Aortic aneurysm (AA) is characterized by pathological dilation at specific predilection sites of the vessel, potentially leading to life-threatening vascular rupture. Aortic aneurysms typic...