Intermittent Clearance of High p21-Expressing Cells Extends Lifespan and Delivers Sustained Health Benefits Research Background With the significant extension of human lifespan, the global elderly population is rapidly increasing. Elderly individuals often face decreased functionality and various chronic diseases in their later years, such as cardi...

Myocardial Infarction Accelerates the Progression of Metabolic Dysfunction-Associated Steatohepatitis by Inducing Immune Inflammatory Response and Periostin Background and Study Motivation Metabolic-associated steatohepatitis (MASLD, formerly NAFLD) is one of the most common chronic liver diseases worldwide, affecting about 25% of the adult populat...

Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...

Clinical, Histopathological, and Genetic Characterization: Insights from Myofibrillar and Distal Myopathies Patients in the Italian Network Background and Research Motivation Myofibrillar Myopathies (MFM) and Distal Myopathies (DM) are a group of rare diseases with complex pathological presentations. The diagnosis process is extremely complicated d...

Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Study on Gender Differences and Stroke Risk Among HIV-Infected Individuals Background Individuals with HIV infection may face a higher risk of stroke, particularly women. However, understanding of whether the influence of various factors on cerebrovascular risk in this population differs by gender and whether these differences contribute to variati...

Research Report on Gender-Specific Association Between Cardiovascular Risk Factors and Migraine Academic Background Migraine is a common neurological disorder. Previous studies have shown that migraine, especially migraine with aura, is associated with cardiovascular events such as myocardial infarction, coronary heart disease, and cardiovascular m...

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...

EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...

Rheumatic Heart Disease Mortality Risk Factors Mortality and Incidence of Rheumatic Heart Disease in Adults Research Background Rheumatic heart disease (RHD) causes over 300,000 deaths annually, primarily in low- and middle-income countries (LMICs). Due to a lack of high-quality epidemiological data, understanding of the incidence and mortality of ...