Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

The Critical Role of Calcium in Skeletal Muscle Function and Its Interaction with Mitochondria and the Endoplasmic Reticulum Academic Background Calcium ions (Ca²⁺) are crucial intracellular signaling molecules, particularly in the excitation-contraction coupling (ECC) of skeletal muscle. The contraction of skeletal muscle relies on the release and...

Digitally Embroidered Metamaterial Biosensor: Non-Contact Physiological Monitoring in Dynamic Environments Recent years have witnessed rapid development of sensor technologies driven by demands in smart vehicles, aviation safety, and health monitoring. However, for physiological signal detection in dynamic environments, traditional sensors face sig...

Personalized Perioperative Dosing of Ivabradine in Noncardiac Surgery: A Single-Centre, Randomised, Placebo-Controlled, Double-Blind Feasibility Pilot Trial Academic Background Perioperative myocardial injury (PMI) is a common complication following noncardiac surgery and is closely associated with postoperative mortality and morbidity. Studies hav...

Use of Coagulation Factor Concentrates and Blood Transfusion in Cardiac Surgery: A Retrospective Cohort Study of Adults with Hereditary and Acquired Bleeding Disorders Academic Background Cardiac surgery is one of the high-risk procedures, especially for patients with bleeding disorders, as it significantly increases the risk of perioperative bleed...

Academic Background Preoperative anemia and red blood cell (RBC) transfusions are closely associated with poorer surgical outcomes. Although RBC transfusions can increase oxygen delivery, they are also linked to an increased risk of infectious complications, thromboembolic events, pneumonia, sepsis, cardiac events, and mortality. Therefore, when st...

Pulmonary Embolism (PE) Overview Pulmonary Embolism (PE) is a serious medical emergency with an annual incidence of approximately 60 to 120 cases per 100,000 people in North America and Europe. Most patients are diagnosed with PE in the Emergency Department (ED), and hospitalization is required for the majority of U.S. patients. Anticoagulation is ...

Association Between Cardiovascular Disease and Breast Cancer Stage at Diagnosis Academic Background Cardiovascular disease (CVD) and cancer are the two leading causes of mortality in the United States. Although they share many common risk factors, recent studies suggest that CVD may directly promote the occurrence and progression of cancer. Specifi...

Whole-Genome Analysis of Plasma Fibrinogen Reveals Population-Differentiated Genetic Regulators with Potential Liver Roles Academic Background Fibrinogen is a crucial coagulation factor and acute-phase reactive protein. Under normal physiological conditions, fibrinogen is abundant in circulation, but during the acute inflammatory response, transcri...

Neuropilin-1 (Nrp1) is a multifunctional transmembrane protein that is abundantly expressed on the surface of various cell types, where it binds to class 3 semaphorins (Sema3), heparan sulfate, and vascular endothelial growth factors (VEGFs). Nrp1 plays a crucial role in angiogenesis and vascular permeability regulation, particularly in the VEGF si...