Somatic CAG Repeat Instability in Intermediate Alleles of the HTT Gene and its Potential Association with a Clinical Phenotype

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
Huntington Disease   CAG Repeat   Somatic Instability   Intermediate Alleles   Neurocognitive Symptoms  

Potential Association between Somatic CAG Repeat Instability in HTT Intermediate Alleles and Clinical Phenotype Research Background Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of CAG trinucleotide repeats (≥36 CAG repeats) in the HTT gene. Intermediate alleles (IAs) with 27-35 CAG repeats are generally not cons...