PFKFB3-Dependent Redox Homeostasis and DNA Repair Support Cell Survival Under EGFR-TKIs in Non-Small Cell Lung Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Non-small cell lung carcinoma   EGFR   PFKFB3   Oxidative stress   DNA repair   ROS-dependent cell death   Metabolic rewiring  

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...