PFKFB3-Dependent Redox Homeostasis and DNA Repair Support Cell Survival Under EGFR-TKIs in Non-Small Cell Lung Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Non-small cell lung carcinoma   EGFR   PFKFB3   Oxidative stress   DNA repair   ROS-dependent cell death   Metabolic rewiring  

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...

Glycometabolic Reprogramming-Induced XRCC1 Lactylation Confers Therapeutic Resistance in ALDH1A3-Overexpressing Glioblastoma

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry,
Glioblastoma   Metabolic reprogramming   Lactylation   Therapeutic resistance   ALDH1A3   DNA repair  

Background Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults, characterized by high recurrence and mortality rates. Despite active chemotherapy and radiotherapy post-surgery, GBM remains insensitive to existing treatment regimens, and patients usually have a poor prognosis. Recent studies indicate that the...