Antisense Oligonucleotides Enhance SLC20A2 Expression and Suppress Brain Calcification in a Humanized Mouse Model

Antisense Oligonucleotides Enhance SLC20A2 Expression and Suppress Brain Calcification in a Humanized Mouse Model

Antisense Oligonucleotide Enhances SLC20A2 Expression and Inhibits Brain Calcification in Humanized Mouse Models Background and Research Questions Primary Familial Brain Calcification (PFBC) is an age-related neurogenetic disorder, characterized by bilateral calcifications in brain regions such as the basal ganglia, thalamus, and cerebellum. PFBC p...