The Genetic Duet of Concurrent RASAL1 and PTEN Alterations Promotes Cancer Aggressiveness by Cooperatively Activating the PI3K–AKT Pathway

Medicine, Endocrinology, Oncology,
cancer aggressiveness   PI3K pathway   PTEN   RASAL1   tumor suppressor gene  

Mechanism of RASAL1 and PTEN Co-Alterations Promoting Cancer Aggressiveness Academic Background Cancer is one of the leading causes of death worldwide, and its occurrence and progression involve abnormalities in multiple genes and signaling pathways. The PI3K-AKT signaling pathway plays a crucial role in cancer, and its overactivation is closely re...