The Genetic Duet of Concurrent RASAL1 and PTEN Alterations Promotes Cancer Aggressiveness by Cooperatively Activating the PI3K–AKT Pathway

Medicine, Endocrinology, Oncology,
cancer aggressiveness   PI3K pathway   PTEN   RASAL1   tumor suppressor gene  

Mechanism of RASAL1 and PTEN Co-Alterations Promoting Cancer Aggressiveness Academic Background Cancer is one of the leading causes of death worldwide, and its occurrence and progression involve abnormalities in multiple genes and signaling pathways. The PI3K-AKT signaling pathway plays a crucial role in cancer, and its overactivation is closely re...

Real-World Overall Survival and Treatment Patterns by PTEN Status in Metastatic Castration-Resistant Prostate Cancer

Medicine, Medical Laboratory Science, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Castration-Resistant Prostate Cancer   Overall Survival   Treatment Patterns   Genomic Testing  

Overall Survival and Treatment Patterns in Metastatic Castration-Resistant Prostate Cancer Patients Based on PTEN Status Academic Background Prostate cancer is one of the most common malignant tumors among men worldwide and a leading cause of cancer-related deaths. Approximately 10%-20% of prostate cancer patients will develop castration-resistant ...

Reactivating PTEN to Impair Glioma Stem Cells by Inhibiting Cytosolic Iron-Sulfur Assembly

Medicine, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
PTEN   Glioma Stem Cells   Iron-Sulfur Clusters   Drug Combination   Desuccination  

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...