Advanced Bioresponsive Drug Delivery Systems for Diabetic Vascularized Bone Regeneration Background The treatment of bone defects in patients with Diabetes Mellitus (DM) remains a significant challenge, as the diabetic microenvironment severely impedes bone regeneration. Various abnormal factors in the diabetic microenvironment, such as hyperglycem...
Insulin Activates Hepatic-Related Neurons in the Paraventricular Nucleus of the Hypothalamus via mTOR Signaling Academic Background Glucose homeostasis is a critical physiological process for sustaining life, with the liver playing a central role in this regulation. The liver maintains blood glucose levels by modulating glycogen production and gluc...
Impact of GLP-1 Receptor Agonists on Axonal Function in Diabetic Peripheral Neuropathy Academic Background Diabetic Peripheral Neuropathy (DPN) is one of the most common complications in patients with type 2 diabetes worldwide, affecting approximately 50% of diabetic patients. The main symptoms of DPN include neuropathic pain, numbness, and in seve...
Dynamic Changes in Estrogen Receptor Alpha (ERα) Promoter Methylation and Drug Resistance in Breast Cancer Cells Background Breast cancer is one of the most common cancers among women worldwide, with approximately 75% of breast cancer patients expressing estrogen receptor alpha (ERα, gene symbol ESR1). ERα is not only an important prognostic marker...
Mechanism of RASAL1 and PTEN Co-Alterations Promoting Cancer Aggressiveness Academic Background Cancer is one of the leading causes of death worldwide, and its occurrence and progression involve abnormalities in multiple genes and signaling pathways. The PI3K-AKT signaling pathway plays a crucial role in cancer, and its overactivation is closely re...
TSH/TSHR Signaling Promotes CD8+ T Cell Exhaustion and Immune Evasion in Colorectal Cancer Background Colorectal cancer (CRC) is one of the most common malignancies worldwide with high morbidity and mortality rates. Although immune checkpoint blockade (ICB) therapy has shown significant efficacy in some patients, the majority of CRC patients, parti...
SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction Research Background Osteoporosis is a common bone disease characterized by reduced bone density and disrupted bone microstructure, leading to an increased risk of fractures. Osteoclasts, the primary cells responsible for bone resorption, play a cri...
The Role of Sirtuins in Obesity and Osteoporosis and Their Therapeutic Potential Academic Background Obesity and osteoporosis (OP) are increasingly severe public health issues worldwide. Obesity is not only closely related to metabolic diseases such as cardiovascular diseases and diabetes but also has a complex association with the occurrence of os...
The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...
Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...