Normalizing Flow-Based Distribution Estimation of Pharmacokinetic Parameters in Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Engineering, Electrical Engineering, Information Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Medical Imaging, Oncology,
normalizing flow   pharmacokinetic parameters   dynamic contrast-enhanced MRI   maximum likelihood estimation   posterior distribution  

In modern medical diagnostics and clinical research, Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) technology provides significant information regarding tissue pathophysiology. By fitting a Tracer-Kinetic (TK) model, pharmacokinetic (PK) parameters can be extracted from time-series MRI signals. However, these estimated PK parameter...