Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERP57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
ALS   protein disulfide isomerase   ERP57   TDP-43 pathology   ER stress  

Study on the Protective Effect of ERP57 on ALS-related Mutant TDP-43 in Neuronal Cells Introduction Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Almost all ALS cases (97%) and about 50% of frontotemporal dementia (FTD) cases show a pathological form of Tar-DNA binding protein-43 (TDP-43), indica...