Efficient Storage and Regression Computation for Population-Scale Genome Sequencing Studies

Information Science, Computer Science, Life Sciences, Bioengineering, Genetics,
genome sequencing   data compression   regression analysis   computational efficiency   rare variants  

With the increasing availability of large-scale population biobanks, the potential of Whole Genome Sequencing (WGS) data in human health and disease research has been significantly enhanced. However, the massive computational and storage demands of WGS data pose significant challenges to research institutions, especially those with limited funding ...

A Statistical Framework for Multi-Trait Rare Variant Analysis in Large-Scale Whole-Genome Sequencing Studies

Medicine, Life Sciences, Biochemistry, Bioengineering, Genetics,
statistical framework   rare variants   multi-trait analysis   whole-genome sequencing   functional annotations  

A New Framework for Multi-Trait Rare Variant Analysis: Multistaar Research Background and Problem Statement With the advancement of next-generation sequencing technologies and the decreasing cost of whole-genome sequencing (WGS), researchers can delve deeper into the impact of rare variants on complex human traits. However, single-trait analysis me...