Depletion of Squalene Epoxidase in Synergy with Glutathione Peroxidase 4 Inhibitor RSL3 Overcomes Oxidative Stress Resistance in Lung Squamous Cell Carcinoma

Medicine, Oncology,
lung squamous cell carcinoma   squalene epoxidase   terbinafine   reactive oxygen species   ferroptosis  

Lung cancer is one of the leading causes of death worldwide, with lung squamous cell carcinoma (LUSC) being a subtype of non-small cell lung cancer (NSCLC), accounting for 20%-30% of all NSCLC cases. Despite significant advancements in lung cancer treatment in recent years, LUSC still lacks effective targeted therapies, and patients have a poor pro...