Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Reduced Graphene Oxide-Mediated Electron–Hole Separation Using Titanium Dioxide Increases the Photocatalytic Antibacterial Activity of Bone Scaffolds

Materials Science, Medicine, Orthopedics, Life Sciences, Bioengineering,
reduced graphene oxide   photocatalysis   reactive oxygen species   antibacterial properties   bone scaffold   titanium dioxide   electron-hole separation  

Study on Reduced Graphene Oxide-Mediated Titanium Dioxide Photocatalytic Antibacterial Bone Scaffolds Academic Background Bacterial infection is one of the most common complications following the implantation of artificial bone scaffolds during bone defect repair. Bacteria form biofilms on the scaffold surface, releasing acids and enzymes that inte...

Electrospun Polyvinyl Alcohol Fibres Incorporating an Antimicrobial Gel for Enzymatically Controlled Reactive Oxygen Species Release

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Life Sciences, Biochemistry, Bioengineering, Microbiology,
antimicrobial   electrospinning   hydrogen peroxide   polyvinyl alcohol   reactive oxygen species   tissue engineering   wound dressing  

Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...

Oxyglutamate Carrier Alleviates Cerebral Ischaemia–Reperfusion Injury by Regulating Mitochondrial Function

Medicine, Neurology, Life Sciences,
cerebral ischaemia–reperfusion injury   mitochondrial function   neuron   oxyglutamate carrier   reactive oxygen species  

The Role of Oxyglutamate Carrier in Cerebral Ischemia-Reperfusion Injury Academic Background Cerebral ischemia-reperfusion injury (I/R) is a significant issue in the treatment of ischemic stroke. Although rapid blood flow restoration through thrombectomy and intravenous rt-PA (recombinant tissue plasminogen activator) administration can effectively...

WWP1 Regulates TXNIP Ubiquitination and Degradation in Acute Myeloid Leukemia Cells via Redox State Modulation

Medicine, Hematology, Oncology, Life Sciences, Biochemistry,
acute myeloid leukemia   ubiquitination   redox homeostasis   reactive oxygen species   WWP1   TXNIP   apoptosis  

WWP1 Regulates Redox State in Acute Myeloid Leukemia Cells by Modulating TXNIP Background Acute myeloid leukemia (AML) is a malignant blood disorder characterized by the abnormal proliferation of immature leukemia cells (leukemic blasts) in the bone marrow. Although significant progress has been made in the treatment of AML in recent years, the lon...

Poldip2 Mediates Brain Vascular Permeability by Regulating ROS-Mediated ZO-1 Phosphorylation and Localization at the Interendothelial Border

Medicine, Neurology, Life Sciences, Cell Biology,
blood–brain barrier   Poldip2   ZO-1   reactive oxygen species   brain endothelial cells  

POLDIP2 Regulates Cerebral Vascular Permeability by Modulating ROS-Mediated ZO-1 Phosphorylation and Localization Background The blood-brain barrier (BBB) is a critical component of the central nervous system (CNS), composed of brain endothelial cells, astrocytes, pericytes, and neurons. Brain endothelial cells form a continuous physical barrier th...

Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Preeclampsia-Induced Apoptosis of Placental Trophoblastic Cells via Inhibiting the Mitochondrial Unfolded Protein Response

Medicine, Obstetrics and Gynecology, Neurology, Life Sciences, Cell Biology, Biochemistry,
preeclampsia   transcutaneous auricular vagus nerve stimulation   acetylcholine   reactive oxygen species   mitochondrial unfolded protein response   placental trophoblastic cells  

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Preeclampsia-Induced Placental Trophoblast Apoptosis by Inhibiting Mitochondrial Unfolded Protein Response Research Background Preeclampsia is a severe obstetric complication affecting 2%-8% of pregnancies worldwide. This disease not only impacts the health of pregnant women but also serio...