Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis

Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...

Aging Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease by Inducing Ferroptotic Stress

Aging Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease by Inducing Ferroptotic Stress

Research Review on Aging-Exacerbated Metabolic Dysfunction-Related Lipid Liver Diseases Academic Background As the aging population increases, metabolic diseases induced by aging are becoming a severe public health challenge. The liver, being the primary metabolic organ, requires special attention to its functional disorders during aging. Studies h...