Endothelin-1-Mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia via Enhanced ATP-P2X4 Receptor Signaling

Medicine, Respiratory System, Basic Medical Sciences, Neurology, Life Sciences, Immunology,
Endothelin-1   Brainstem glial activation   Airway vagal hypertonia   ATP-P2X4 receptor   Asthma   Sprague–Dawley rats  

Endothelin-1 Mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia via Enhanced ATP-P2X4 Receptor Signaling Academic Background Asthma is one of the major non-communicable diseases globally, causing a heavy social and economic burden. Its main clinical symptoms include airflow obstruction, chronic airway inflammation, incre...