Alveolar Regeneration: Role of p63+ Progenitor Cells Derived from Airway Secretory Cells Background Introduction Effective gas exchange in the lungs relies on the precise structure and function of various epithelial cells, distributed across two distinct structural regions: ductal airways and alveoli. When alveoli are damaged (e.g., due to inhaled ...
Persistent Expression of Amphiregulin (AREG) in Intermediate Alveolar Stem Cells Drives Progressive Pulmonary Fibrosis Background Fibrotic diseases are a leading cause of up to 45% of deaths in developed countries. Pulmonary fibrosis is a disease characterized by alveolar structure damage and impaired gas exchange, with Idiopathic Pulmonary Fibrosi...
Background and Problem In recent years, there has been significant progress in research on the multifaceted roles of mitochondria within cells. Aside from being the energy source of the cell, mitochondria also play crucial regulatory roles in processes such as cell proliferation, differentiation, and self-renewal, attracting widespread attention in...
Research Background With global population aging, the number of lung resection surgeries has increased significantly, including primary lung cancer resection, removal of lung metastases, and surgeries to treat lung infections or emphysema. However, little is known about the systemic stress response after thoracic surgery and interventions to improv...
Optimization of Respiratory Pressure Under Mechanical Ventilation Guidance - A Study on Improving Local Lung Biomechanics Mechanical ventilation is commonly used in clinical practice to treat acute respiratory distress syndrome (ARDS) and prevent pulmonary complications after general anesthesia. However, mechanical ventilation can cause harmful str...
The Impact of Super-Relaxed Myosin on Diaphragm Dysfunction in Ventilated Patients Background Weak diaphragm contraction is a common problem in patients receiving mechanical ventilation in intensive care units (ICUs). This leads to difficulties in weaning patients off ventilators, increases mortality rates, and imposes a significant economic burden...
A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...
Potential Improvements in Lung Nodule Measurement Precision in Computed Tomography Using Artificial Intelligence Software and Its Impact on Clinical Practice - A Simulation Study Background Accurate measurement of lung nodules is crucial for the detection and management of lung cancer. Nodule size is the primary basis for risk classification in exi...
Dopamine Modification of TPI1 Inhibits Ferroptosis Signaling in Vascular Endothelial Cells, Promoting Lung Regeneration and Inhibiting Fibrosis Background The regenerative capability of the lung enables it to restore its original functional tissue after injury. However, if this regenerative process is disrupted, it often leads to maladaptive repair...
Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...