Fibroblast-Specific TGF-β Signaling Mediates Cardiac Dysfunction, Fibrosis, and Hypertrophy in Obese Diabetic Mice

Medicine, Endocrinology, Cardiovascular System,
Diabetic cardiomyopathy   TGF-β   Fibrosis   Heart failure   Hypertrophy  

New Mechanism of Diabetic Cardiomyopathy: The Role of Fibroblast-Specific TGF-β/Smad3 Signaling Pathway Research Background Diabetes is a significant risk factor for cardiovascular diseases and heart failure (HF) globally. Diabetic patients not only face risks of macrovascular complications such as hypertension and atherosclerosis but are also pron...

Deep Phenotyping of Testosterone-Prompted Fibrosis in Arrhythmogenic Right Ventricular Cardiomyopathy Using iPSC-Derived Engineered Cardiac Spheroids

Medicine, Cardiovascular System, Life Sciences,
Arrhythmogenic Right Ventricular Cardiomyopathy   Gender Difference   Cardiac Spheroids   Testosterone   Fibrosis   iPSC   Cardiac Fibrosis  

iPSC-Derived Engineered Cardiac Spheroids Reveal the Fibrotic Role of Testosterone in Arrhythmogenic Right Ventricular Cardiomyopathy Academic Background Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by the replacement of myocardial tissue with adipose and fibrous tissue, leading to arrhythmias,...