Deep Phenotyping of Testosterone-Prompted Fibrosis in Arrhythmogenic Right Ventricular Cardiomyopathy Using iPSC-Derived Engineered Cardiac Spheroids

Medicine, Cardiovascular System, Life Sciences,
Arrhythmogenic Right Ventricular Cardiomyopathy   Gender Difference   Cardiac Spheroids   Testosterone   Fibrosis   iPSC   Cardiac Fibrosis  

iPSC-Derived Engineered Cardiac Spheroids Reveal the Fibrotic Role of Testosterone in Arrhythmogenic Right Ventricular Cardiomyopathy Academic Background Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized by the replacement of myocardial tissue with adipose and fibrous tissue, leading to arrhythmias,...

Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
TGF-β   signaling pathway   NK cells   hepatocellular carcinoma   iPSC   anti-tumor   immunotherapy  

Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...