An Electromechanical Model-Based Study on the Dosage Effects of Ranolazine in Treating Failing HCM Cardiomyocyte

Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease, affecting approximately 1 in 500 people globally. The primary characteristic of HCM is asymmetric hypertrophy of the myocardium. In its early stages, it may manifest as hyperdynamic contraction of the left ventricle (LV). However, as the disease progresses, patients may develop ...

Fibroblast-Specific TGF-β Signaling Mediates Cardiac Dysfunction, Fibrosis, and Hypertrophy in Obese Diabetic Mice

New Mechanism of Diabetic Cardiomyopathy: The Role of Fibroblast-Specific TGF-β/Smad3 Signaling Pathway Research Background Diabetes is a significant risk factor for cardiovascular diseases and heart failure (HF) globally. Diabetic patients not only face risks of macrovascular complications such as hypertension and atherosclerosis but are also pron...