Native DGC Structure Rationalizes Muscular Dystrophy-Causing Mutations
Academic Background Duchenne Muscular Dystrophy (DMD) is a severe X-linked recessive disorder characterized by progressive muscle wasting, leading to premature mortality. The cause of DMD is mutations in the gene encoding dystrophin, a protein that, along with other proteins at the muscle cell membrane, forms the Dystrophin-Glycoprotein Complex (DG...