NF1 mutation-induced neuronal hyperexcitability drives murine optic glioma growth and can be targeted by lamotrigine treatment

Medicine, Neurology, Oncology, Life Sciences, Immunology, Genetics,
NF1 gene mutation   neuronal hyperexcitability   optic glioma   murine models   lamotrigine treatment  

Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...