Senescent Lung Fibroblasts in Idiopathic Pulmonary Fibrosis Facilitate Non-Small Cell Lung Cancer Progression by Secreting Exosomal MMP1

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Idiopathic Pulmonary Fibrosis   Non-Small Cell Lung Cancer   Exosomes   MMP1   PI3K-AKT-mTOR Pathway   Senescence-Associated Secretory Phenotype   Tumor Microenvironment  

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...