TH17-Intrinsic IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation

TH17-Intrinsic IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Immunology,
Autoimmune Neuroinflammation   TH17 Cells   Steroid Resistance   IL-1β   STAT5   Central Nervous System  

TH17 Endogenous IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation Academic Background Steroid resistance is a major challenge in managing various inflammatory diseases, including autoimmune neuroinflammation. T helper 17 (TH17) cells are widely believed to be associated with steroid resistance. However, the specific mechani...