Gain-of-Function Mutations of TRPV4 Acting in Endothelial Cells Drive Blood-CNS Barrier Breakdown and Motor Neuron Degeneration in Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry,
TRPV4   Blood-CNS Barrier   Endothelial Cells   Motor Neuron Degeneration   Mouse Model   Mutations   Therapeutic Strategy  

This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...