Inhibition of Mannan-Binding Lectin Associated Serine Protease-2 Reduces Cognitive Deficits in a Mouse Model of Severe Traumatic Brain Injury

Medicine, Neurology, Neurosurgery, Life Sciences, Immunology,
Traumatic Brain Injury   Lectin Pathway   MASP-2   Cognitive Deficits   Antibody Therapy   Mouse Model  

Review of Research on the Treatment Potential for Cognitive Deficits in Traumatic Brain Injury Research Background Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. In Europe, the annual incidence of TBI is at least 4 million cases, imposing a heavy burden on patients, society, and health systems, yet the available ...

Gain-of-Function Mutations of TRPV4 Acting in Endothelial Cells Drive Blood-CNS Barrier Breakdown and Motor Neuron Degeneration in Mice

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry,
TRPV4   Blood-CNS Barrier   Endothelial Cells   Motor Neuron Degeneration   Mouse Model   Mutations   Therapeutic Strategy  

This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...