Thiazoplanomicin, a New Thiazolyl Peptide Antibiotic from the Leaf-Litter Actinomycete Actinoplanes sp. MM794L-181F6

Discovery and Research of the New Antibiotic Thiazoplanomicin Academic Background In recent years, the issue of antibiotic resistance has become increasingly severe, particularly with Neisseria gonorrhoeae (gonococcus), a common sexually transmitted pathogen. Gonococcus can rapidly develop drug resistance, rendering traditional antibiotics such as ...

Semisynthetic Guanidino Lipoglycopeptides with Potent In Vitro and In Vivo Antibacterial Activity

Development of Semi-synthetic Guanidino-lipoglycopeptide Antibiotics and Study of Their In Vitro and In Vivo Antibacterial Activities Background With the slowdown in antimicrobial drug development and the rapid increase of resistant strains, antibiotic resistance has become a major threat to human health. Particularly, Gram-positive pathogens such ...